Of Duchenne / Becker muscular dystrophy is a progressive muscle disease, which is caused by abnormal resistance to muscle atrophy protein. Spina bifida feet paralysis is characterized by most of the upper limb is not affected. We reported one case of Becker muscular dystrophy accompanied by the incidence of spina bifida. Upper limb muscle biopsy showed changes of muscular dystrophy, which changes rarely occur in the lower extremities. The results show that the limit excessive movement plays an important role for dystrophin-deficiency diseases.
Department of Child Development, Kumamoto University School of Medicine, 1-1-1 Honjou Kumamoto 860-0811, Japan.
Duchenne/Becker muscular dystrophy is a progressive muscle disease, which is caused by the abnormality of dystrophin. Spina bifida is characterized by paralysis of the feet, with most of the upper extremities not being affected. We report here on the first case of Becker muscular dystrophy coinciding with spina bifida. The muscle biopsy specimens of the patient showed dystrophic changes in upper extremities, but clearly less in lower extremities. The results show that the restriction of excessive exercise is important for dystrophin deficiency disease.